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![]() 2.0 that encrypts your passwords, to physical security options, to a self-healing BIOS with BIOS Guard and Boot Guard, to smart USB protection-we’ve got you covered. Kaspersky Rescue Disk is a full software suite with tools like free bootable Antivirus, a web browser, and a Windows Registry Editor. It’s designed to be used when a regular Antivirus program fails in detecting and removing viruses from a PC.
![]() Wikidata, as was done in this study) and can be used in graph based applications. There are not many tools yet that can process and use nanopublications, but due to their structure, they can be implemented in graph based databases (e.g. ![]() Nanopublications are usually accompanied by a meta data header, and if correctly formed and made available they are automatically FAIR (Findable, Accessible, Interoperable and Re-usable 9). Nanopublications are short information sequences built from identifiers and ontologies with embedded provenance, that especially allow data mining and automated read-out 8. In order to describe the content on this spreadsheet and to provide it in a structured way we developed a dedicated version of the DisGeNET semantic model to produce a resource description framework (RDF) file and a set of nanopublications. The data are annotated with OMIM identifiers for the disease, gene identifiers (HGNC 6 and Ensembl 7) for the gene, and PubMed identifiers (PMIDs) for the literature. We produced a mapping dataset, which links rare, monogenic diseases to their causative genes (and vice versa), backed up by the publication which proves the genetic cause for a disease for the first time, or historic provenance. This information is very useful for historic perspectives on genetic and rare disease research. However, none of these databases provides a list or a dataset that links the unique publication, which described the link between the gene and the disease first. The given literature lists, which support gene-disease associations, are useful to provide accumulated provenance for this association. OMIM is the online version of the genetic (Mendelian) disease encyclopaedia that provides information in the form of a literature list for a disease or a gene and provides gene-disease mapping spreadsheets, e.g. Orphanet does as well but focuses more on patient care related information. DisGeNET provides an extensive collection of linked data including a semantic model. in the form of manually curated or text mining derived literature lists. Some well-known databases like OMIM ( Orphanet ( ), and DisGeNET 4 include provenance - e.g. Many genotype-phenotype databases link information about rare diseases, their causative genes, and gene variants, respectively 3. Within this process mapping of genetic data, identifiers and information is required in several ways. There are several bioinformatics workflows available to go from the raw data to the detection of the causative mutation, see e.g. For the identification of the disease-causing variant, experts cross-check with variant databases and use variant pathogenicity prediction algorithms. ![]() A typical human individual has about 4.1–5 Mio variants compared to the reference genome 1. Identification of the disease-causing mutation in the plethora of genetic variation an individual human carries is a difficult task in the diagnosis of rare diseases. Our analysis revealed the timeline of rare disease and causative gene discovery and links them to developments in methods.ĭescriptions of unusual diseases date back until the ancients, but rare genetic diseases are a relatively new chapter in the history of medicine as genes as carriers of hereditary diseases were only discovered in the middle of the last century (see e.g. This dataset relies on publicly available data and publications with a PubMed identifier, but by our effort to make the data interoperable and linked, we can now analyse this data. The data are available under CC0 license as spreadsheet and as RDF in a semantic model modified from DisGeNET, and was added to Wikidata. The PubMed identifiers of the scientific publications, which for the first time described the rare diseases, and the publications, which found the genes causing the diseases were added using information from OMIM, PubMed, Wikipedia,, and Google Scholar. We assembled a collection of 4166 rare monogenic diseases and linked them to 3163 causative genes, annotated with OMIM and Ensembl identifiers and HGNC symbols. Here, we describe a dataset with information about monogenic, rare diseases with a known genetic background, supplemented with manually extracted provenance for the disease itself and the discovery of the underlying genetic cause. ![]() Simple controls: The game can be played with just one button, making it easy to learn but difficult to master.Power-ups: The game includes power-ups such as shields and speed boosts, which can help the player stay alive and gain an advantage over their opponents in multiplayer mode.Watch out the explosion barrels and be within the area to make up to the next level. ![]() Multiple game modes: The game offers several modes, including a single-player campaign, multiplayer races, and a survival mode, providing a variety of challenges and replayability. Use gravity to make the ball move forward and avoid the obstacles on the way.Gravity-defying gameplay: The game challenges the player to navigate a track that can be flipped upside down at any time, adding a unique twist to traditional running games.Player 2-8: Define it from the game menu.The game features several modes, including a single-player campaign with 30 levels, a multiplayer race mode where up to 8 players compete to reach the finish line first, and a survival mode where players try to stay alive as long as possible on an endless track.Ĭontrols are simple no matter what device you're on. The twist is that the track can be flipped upside down at any time, forcing the player to adjust their strategy and reflexes to stay alive. The track is divided into lanes, and the player can switch between these lanes to avoid obstacles and collect power-ups. You're switching the center of gravity to be above or below your screen. Because you're not really running in this online game, the character with the big shoes does it for you. A free one-button jump'n'run game with a twist. In G-Switch 3, the player controls a character who is constantly running forward on a futuristic, gravity-defying track. G-Switch is an addictive multiplayer parkour game for up to 6 players. In particular, you can change the keyboard shortcut to control the character when participating in this game mode.G-Switch 3 is a fast-paced running game that can be played either solo or with up to 8 players on a single keyboard. In this mode, you can choose the number of people to join you, the minimum will be two players and the maximum is 8 people. You can choose to play against the automaton, or play with friends. Finally, the multiplayer mode is also the mode that makes G-Switch more outstanding than many other running games. The second mode is Endless, which is similar to the previous mode, but this is where your track is endless for you to explore. In normal mode, you will run in the maze through each level, and then your speed will increase as you run into the speed-up box. You have three modes to choose from when playing this game. In this game, the track is completely normal like in other games, but the speed is extremely fast. There are more than a hundred levels that you need to unlock. The rule is simple, you can only pass through an obstacle if it's the same color as your ball. However, if you don't like this exciting form of racing you can run in Run 3. Speedy Ball 3D is a WebGL game that will definitely give you that adrenaline rush. Release Date November 2016 and now with a new update in January 2019. Also, make sure you try other similar gravity falls games like these cool math games run 3 in G-Switch 2, Crazy Roll 3D, Bike Racing HD Space, Steep, and Gravity Guy. GSwitch3&glSE G-Switch 3 - Free Online Game - Start Playing Kizi WebG-Switch 3. Run for your life in this new game 'G-Switch 3' and have a blast online for free on. That is, in G-Switch 3, when running, your feet can be on the ceiling while your head is facing the ground and vice versa. G-Switch 3 on the App Store WebRun and flip gravity at lightning-speed. However, this run is not like the track in other running games, it is a gravity run. In front of you is a winding maze, and the challenge for you is to control the robot to overcome sharp obstacles in this maze. Start the game, and it can be seen that you will play a character that looks like a robot but is very agile. Let's start the special game! Join running on the exciting racing in G-Switch 3 In the game you can play with up to 7 friends in Multiplayer mode, or play game solo with Campaign and Endless modes. This is a game that has a special track because it is a gravity track. G-Switch 3 is a gravity defying skill game and the third installment of the G-Switch series from Serius Games. Join G-Switch 3 to explore the dangerous maze. ![]() Although an interesting sight, it is a bit of a drive (if there's any trafic) for someone leaving the Bay area. As far as location, it is one of the northernmost large winery in the Sonoma area. A very unique property and one I would highly recommend you consider making a day trip to if you are in the Napa/Sonoma area.įrancis Ford Coppola is somewhat unique in the Napa/Sonoma area in the sense that it does a fairly good job to offer a "premium" experience in a very nice setting while being relatively family friendly. We saw people and families swimming, lounging poolside and playing bocce ball. Outside is so amazing, with a huge pool surrounded by little cabanas (little change rooms) that people can rent for the day. We did not have time to do some tastings but the tasting room was busy. There's also a great gift shop and of course lots of fantastic wines for purchase. After lunch, we took a tour inside the winery and the movie gallery with all it's authentic movie memorabilia, including a glass show case filled with FFC Academy Awards. I found my glass of Reserve Russian River Pinot Noir to be okay but not as delicious as I'd hoped it would be as it didn't have that distinct RR pinot deliciousness to it. The red house wine Rosso at $5.00 was also surprisingly quite good as a table wine and recommended by our relative who had enjoyed it here before. I had a glass of the Sofia Blanc de Blanc before my meal which at $6.50 a glass was quite nice for the price. Huge! Our relatives shared and absolutely loved the Marrakesh Lamb for two ($42), a stew like meal cooked and served piping hot in this neat clay pot thing (I don't like lamb, otherwise, my husband would have ordered this dish too but it is served for two people). My husband enjoyed his rack of lamb and I my Chicken Mattone ($24) - half a chicken cooked flat under a brick. Our waiter recommended some of their classic favourites. There was space available inside the restaurant but we opted for the outside patio where we were surrounded by a beautiful scenic view of the vineyards. My husband and I visited relatives in the area while vacationing in Napa and the four of us had a fantastic lunch at the winery at their flagship restaurant Rustic. If you are on a tight schedule or have only a few days in the area, Coppola Winery needs to be on your Must Do list. We were very happy to discover many great wines at affordable prices and, key for us Canadians, wide distribution, meaning we will be able to pick up Coppola wines on our regular visits to Seattle. ![]() Then it was inside to tour the exhibits, the closest we will ever get to an Academy Award! There are many staff throughout the rooms, very knowledgable and eager to give assistance. The 1/2 Muffaletta sandwich is enough for 2 people. We dragged a small table into the shade of one of many trees on the patio and enjoyed and fabulous el fresco lunch. As it was near lunch time the first decision was whether to eat inside at Rustic or outside at one of the many small tables surrounding the Patio bar and the pool. The parking lot was crowded (usually something that turns us away) but the setting was so beautiful we decided to press on. So on a beautiful sunny day of the Labour Day weekend, we decided to visit. Whenever we asked (our resort host, the welcome centre host, other guests, other merchants) about "must see" wineries one answer always came back: "Coppola". Both can be purchased online and in stores or will be served at Tanino in Westwood, Via Alloro in Beverly Hills and Venice’s The Other Room.This is our first visit to the Wine Area of Northern California. The sparkling pink stuff is retailing for $19 for the 750ml bottles and $20 per 4-pack of Minis. Since 2004, the Sofia collection has expanded to include Blanc de Blancs Minis, Riesling, a still Rosé, Chardonnay, a limited-edition Méthode Champenoise and now, the Sofia Brut Rosé. which debuted its pretty-yet-playful peach 187ml cans (including straws) over a decade ago. ![]() ![]() The 2016 Sofia Brut Rosé packaging resembles its predecessor, the Sofia Blanc de Blancs. “Unlike Sofia’s still rosé, which is crafted from Rhone varietals, Sofia Brut Rosé is made from a blend of Pinot Noir and Chardonnay, offering aromatic flavors that pair well with assorted cheeses and charcuterie, hors d’oeuvres, shellfish and spicy Asian cuisine,” says Corey Beck, FFCW’s president and director of winemaking. Millennials have been obsessing over the pink drink in recent years, elevating the popularity of rosé online wine club Winc told Fortune their year-over-year rosé orders jumped 300% in 2016. Sundance: Inside Fest's Hottest Parties and Events (Updating) ![]() ![]() There’s a function that allows you to search for similar images on Google. Screenshots can be saved locally, uploaded to the web, shared on social networks. Installing Lightshot on a PC is an effortless task. Lightshot is available for multiple platforms: Windows, Mac OS X, Internet Explorer, Firefox, Chrome. You can do that and more with the free application Lightshot. Take a screenshot, annotate it, and upload it to the web. ![]() Next up, you can annotate the screenshot: draw using a pencil, add a line, add an arrow, add a rectangular box, add some text, use a marker.Īnd last but not least, you must choose what you want to do with the screenshot: save it to the location of your choice, copy it to the clipboard and paste it in the application of your choosing, print it out, search for similar images on Google, share it on social networking sites, upload it to the web. Select a rectangular area and Lightshot will take a screenshot of that area. Alternatively, you could use the Print Screen button to achieve the same effect.įirst up, you must select the region that will be captured. On the Mac OS, you can take screenshot in the part or in the whole using Command+Shift+4 without using the LighShot software. Left click the icon and you will be able to take a screenshot. Right click the icon and you will be presented with a context menu that features the following entries: Sign In, Take Screenshot, About, Exit. While Lightshot is running on your Windows-powered machine, you will see an icon in the system tray. Lightshot is also available as a browser extension for Microsoft’s Internet Explorer, Mozilla’s Firefox, and Google’s Chrome web browser. Lightshot is available as an installer for Microsoft’s Windows operating system and for Apple’s Mac OS X. That is, in a nutshell, the sort of functionality you can expect to get from Lightshot. When you’re done, you can copy the screenshot, save it locally, upload it to the web, or share it on social networks. Simple interface, nothing useless and light weight. The application will then allow you to annotate the screenshot – draw on it, add a piece of text, highlight areas, and so on. Lightshot is the fastest way to take a customizable screenshot. Click the taskbar icon or hit the Print Screen button and Lightshot will take a screenshot. ![]() Amtrac and Mechanized Infantry provide the most Defense.The combined total Defense of all units in the division.Prevents HP damage, but Organization is still lost through prolonged battle.The number of attacks a division can block in one hour of combat when it is the defender.Anti-air weaponry provides the most Air Attack.The combined total Air Attack of all units in the division.Reduces the effectiveness of enemy air operations, potentially removing air superiority.Damages enemy aircraft attacking the division.Anti-air weaponry also provides decent Hard Attacks in a pinch.Anti-tank weaponry provides the most Hard Attacks.Artillery provides the most Soft Attacks.The combined total of all Soft and Hard Attacks among the units in the division.hard attacks against a division with no tanks) are wasted Hard attacks target tanks and other armored units.Soft attacks target infantry, cavalry, and other unarmored units.The total number of attacks made by the division in each hour of combat.A baseline Field Hospital reduces the experience lost to casualties by ten percent.Affects the amount of experience lost by the division as it suffers casualties.A baseline Field Hospital provides twenty percent Trickleback to its division.Only provided by Field Hospital Support Companies.The percentage of casualties sustained by the division that will return to the manpower pool instead of dying.Baseline Maintenance Support Companies boost all equipment's reliability in their division by five percent (expressed as Reliability Bonus in the division's stats).Vehicles can be modified to increase their reliability.The division's average Reliability gives an at-a-glance look at its overall resistance to attrition. ![]() Reliability is checked for each equipment type in the division individually.Whenever a division is suffering from attrition (usually due to weather, partisans, or lack of supply) a small percentage of equipment is lost daily.Resistance to vehicles and equipment breaking down in the field.A baseline Logistics Support Company reduces the total Supply Use of its division by ten percent.The total combined Supply Use of all units in the division.A division lacking supply due to insufficient resources or being cut off by the enemy will degrade and eventually disband.Supply is sent from cities to theaters of war in order of the priority you set.The amount of supply a division requires operating day-to-day.The total combined Weight of all units in the division.The higher this number is, the more difficult it will be to transport the division by sea or air.The total combined Suppression of all units in the division.While present in states you're occupying from another nation, a division's Suppression will slow or stop the growth of rebel and partisan activity there.Recon Support Companies are the only way to increase a division's Reconnaissance stat.The division's General will add their Reconnaissance stat to the total in combat.The total combined Reconnaissance of all units in the division.If one side's total is higher, that side has a better chance of effectively countering the enemy's Tactics during each battle phase.The total Reconnaissance of all divisions involved in a battle is compared to the total Reconnaissance of all opposing divisions.The mean average Recovery Rate of all units in the division.This number is added to the base recovery for all divisions determined by their current supply status.Organization recovered per in-game hour.Armored divisions should include a significant motorized or mechanized infantry presence if you want them to survive. The mean average Organization of all units in the division.A unit at 0 Organization cannot fight and will automatically retreat if attacked.Moving and fighting reduces a division's Organization, while staying in one place without combat replenishes it.Tanks have a very low HP, relying on their armor to avoid damage.The total combined HP of all units in the division.A division reduced to 0 HP is destroyed permanently.As long as a division has HP left, it can eventually recover to full strength as long as it is supplied with manpower and equipment.A division's combat effectiveness is proportional to its remaining HP.The total amount of damage a division can take before being destroyed.A division composed of tanks and motorized infantry with a single unit of leg infantry will move at walking speed (4kph).A division's Max Speed is always restricted to the lowest speed among its units.Determines how quickly the division can get over land from one place to another on the map. ![]() You work with a leading ledger and with non-leading ledgers. Under Define Document Types for Entry View, you make the document type settings for postings in the entry view that effect all ledgers and for postings to the leading ledger. Here, you make the settings specifying the document type for postings to non-leading ledgers. The IMG activity documentation on Define Document types for Entry View in a Ledger states the following:ĭefine Document Types for Entry View in a Ledger *Recommendation: In the view V_FAGL_BELNR_LD document types should be assigned to the number ranges 91-95. The number range is assigned to the combination of Ledger and Document type (RLDNR + BLART).The menu path via IMG for same is Financial Accounting (New) -> Financial Accounting Global Settings (New) -> Ledgers -> Document -> Document Types -> Define Document Types for Entry View in a Ledger.The customizing view is V_FAGL_BELNR_LD.For ledger specific postings document types for the entry view of a non-leading ledger.Document Types for Entry View in a Ledger ![]() Postings for non-leading ledgers: You make these settings under Define Document Types for Entry View in a Ledger.īy segregating the ledger-related postings (here, the leading ledger) in a separate number range, you ensure the contiguous assignment of document numbers at the ledger level for each number range.Assign a unique number range to this document type.ĭocument Type SX, Closing Postings, Number Range 90 Postings only for the leading ledger: Define a separate document type for these postings.In the case of postings that do not have the same effect on all ledger, proceed as follows: Example: Document Type SA, G/L Account Document, Number Range 01 Document Type SB, G/L Account Posting, Number Range 12 Also assign a number range to the document types. If you work with a leading ledger and with non-leading ledgers, proceed as follows: Since the majority of postings has the same effect in all ledgers, define in this IMG activity the document types for the entry view for postings that affect all ledgers.Also assign a number range to the document types.ĭocument Type SA, G/L Account Document, Number Range 01ĭocument Type SB, G/L Account Posting, Number Range 12 If you only work with one ledger (the leading ledger), proceed as follows: In this activity, define for all postings the document types for the documents in the entry view.This documentation describes the special procedure for setting up document types for New General Ledger Accounting.įor general information about defining document types, see Define Document Types. Document types are used to differentiate the business transactions and to manage how document are stored. ![]() In this activity, you define your document types. The IMG activity documentation on Define Document types for Entry View states the following:
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